Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes
AE Muller, J DeJongh, PM Oostvogel… - American journal of …, 2008 - Elsevier
OBJECTIVE: This study was undertaken to study the pharmacokinetics of intravenously
administered amoxicillin in pregnant women with preterm premature rupture of the
membranes (PPROM). STUDY DESIGN: Healthy women with PPROM were recruited and
treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained
from the opposite arm and concentrations determined with the use of high-pressure liquid
chromatography. Nonlinear mixed-effects modeling was performed in nonlinear mixed effect …
administered amoxicillin in pregnant women with preterm premature rupture of the
membranes (PPROM). STUDY DESIGN: Healthy women with PPROM were recruited and
treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained
from the opposite arm and concentrations determined with the use of high-pressure liquid
chromatography. Nonlinear mixed-effects modeling was performed in nonlinear mixed effect …
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